Current Issue : January - March Volume : 2021 Issue Number : 1 Articles : 5 Articles
Urinary tract infections (UTIs) are one of the most common reasons for antibiotic\nprescriptions among women worldwide. UTIs are also associated with intra- and postoperative\ncatheterization, which is an essential component of many gynecological surgical procedures,\nincluding midurethral sling (MUS) placement. The aim of this study was to compare the incidence\nof UTI subsequent to a MUS procedure. The study involved 562 female patients who underwent\nMUS procedures due to stress urinary incontinence (SUI). Patients were assigned in a 1:1 ratio to two\nstudy groups: patients receiving 500 mg of ciprofloxacin three times a day for 3 consecutive days\nafter surgery or patients receiving 5 mL of Canephron taken orally three times a day for 3 weeks.\nAfter analyzing the collected data, it was found that in the group of patients receiving ciprofloxacin,\n29 women (10.98%) had a UTI, whereas in the group of patients receiving Canephron, 36 women\n(13.64%) had a UTI within 6 months after the patientâ??s MUS procedure. No statistically significant\ndifference between the two groups was noted. Postoperative prophylaxis with a phytodrug can be\nperceived as an attractive option in the reduction of antibiotic consumption among female patients\nafter a MUS procedure....
Background: In recent years, proton pump inhibitors (PPIs) have been investigated at high-dose\nto modulate tumor microenvironment acidification thus restoring chemotherapeutic sensitivity. This is the\nfirst trial to study activity and safety of repurposing high dose rabeprazole combined with metronomic\ncapecitabine (mCAP). Methods: A phase II study in which patients with gastrointestinal cancer,\nrefractory to standard treatments, who had a life expectancy..................................
CAP7.1 is a novel topoisomerase II inhibitor, converted to active etoposide via\ncarboxylesterase 2 (CES2), with signals of efficacy in treatment-refractory solid tumours. In a Phase II\ntrial, 27 patients with advanced biliary tract cancers (BTC) were randomised 1:1 to CAP7.1 plus best\nsupportive care (BSC), or BSC alone, with crossover to CAP7.1 upon disease progression.............................
In mice vaccination with Streptococcus pneumoniae results in an increase in anti-oxLDL IgM\nantibodies due to mimicry of anti-phosphorylcholine (present in the cell wall of S. pneumoniae) and\nanti-oxLDL IgM. In this study we investigated the human translation of this molecular mimicry\nby vaccination against S. pneumoniae using the Prevenar-13 vaccine. Twenty-four healthy male\nvolunteers were vaccinated with Prevenar-13, either three times, twice or once in a double-blind,\nplacebo-controlled, randomized single center clinical study. Anti-pneumococcal wall, oxLDL and\nphosphorycholine antibody levels were measured at a fixed serum dilution, as well as circulating\nlipid levels over the course of 68 weeks. A significant increase in anti-oxLDL IgG and IgM was seen in\nthe group receiving two doses six months apart compared to the placebo. However, these differences\nwere not observed in the groups receiving a single dose, two doses one month apart, or three doses.\nThis study shows that vaccination............................
Impaired fasting glucose (IFG) is a condition that precedes diabetes and increases the\nrisk of developing it. Studies support the hypoglycemic effect of Cynara scolymus (Cs) extracts due\nto the content of chlorogenic acid, which is a potent inhibitor of glucose 6-phosphate translocase\nand of dicaffeoylquinic acid derivatives that modulate the activity of alpha-glucosidase. Given this\nbackground, we investigated whether a new highly standardized Cs extract could improve glycemic\ncontrol, insulin sensitivity and other metabolic parameters (total cholesterol (TC), low-density\nlipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C) Triglycerides,\nApolipo protein B (ApoB), Apolipo protein A (ApoA), waist circumference, visceral adipose tissue\n(VAT) by dual-energy X-ray absorptiometry (DXA) in overweight subjects..................................
Loading....